Expression of manganese superoxide dismutase in colorectal carcinoma and its relationship with clinicopathological findings.
- Author:
Xiao LI
1
;
Zi-Qin SUN
;
Zhi WEI
;
Jing NIU
;
Xiao-Feng LIU
;
Wei WANG
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Colorectal Neoplasms; enzymology; pathology; Female; Humans; Male; Middle Aged; Superoxide Dismutase; metabolism
- From: Acta Academiae Medicinae Sinicae 2011;33(6):670-674
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the expression of manganese superoxide dismutase (MnSOD) in colorectal carcinoma and its relationship with the clinicopathological findings.
METHODSThe expressions of MnSOD in colorectal carcinoma, adenoma, and adjacent corresponding intestinal mucosal tissues were detected by immunohistochemistry and reverse transcription-polymerase chain reaction (RT-PCR). The relationship between MnSOD expression level in colorectal adenoma and clinical parameters was analyzed.
RESULTSThe expression of MnSOD was negative in adjacent corresponding colorectal tissues. The positive expression rate of MnSOD was 44% (11/25) in colorectal adenoma and 76% (19/25) in colorectal carcinoma (P < 0.05 when compared with the colorectal adenoma and its adjacent tissues). The expression of MnSOD was positively correlated with histopathological grades (P < 0.05) but not with other clinicopathological findings (P > 0.05).
CONCLUSIONThe expression of MnSOD may be associated with the carcinogenesis and progression of colorectal carcinoma, and therefore may be used as a new biomarker.
