Cell reprogramming: control key genes to obtain needed cells.
- Author:
Xi-Ning PANG
1
Author Information
1. Department of Stem Cells and Regenerative Medicine, Key Laboratory of Cell Biology of Ministry of Public Health, China Medical University, Shenyang 110001, China. pxining@yahoo.com
- Publication Type:Journal Article
- MeSH:
Animals;
Cell Dedifferentiation;
genetics;
Cell Differentiation;
genetics;
Cellular Reprogramming;
Gene Expression;
Humans;
Nuclear Transfer Techniques
- From:
Acta Academiae Medicinae Sinicae
2011;33(6):689-695
- CountryChina
- Language:Chinese
-
Abstract:
Cell reprogramming is a progress in which the memory of a mature cell is erased and then the cell develops novel phenotype and function; ultimately, the fate of the cell changes. Cell reprogramming usually occurs at genes expression levels that no genomic DNA sequence change will be involved. By changing the programs of the genetic expressions of cells in terms of space and time, cell reprogramming alters the differentiation of cells and thus produces the required cells. Further research on cells reprogramming will elucidate the mechanisms that govern the cell development, and thus provides more information of the sources of seed cells used for regeneration medicine. More cells differentiated from many terminally differentiated cells will be obtained, which is extremely important for the understanding of molecular differentiation and for the development of cell replacement therapy. This article summarizes the classification, influencing factors, approaches and latest advances of cells reprogramming.
