Research advances in suppressor of cytokine signaling 3.
10.3881/j.issn.1000-503X.2012.02.015
- Author:
Na LIN
1
;
Xiao-guang YAO
;
Nan-fang LI
Author Information
1. Institute of Xinjiang Hypertension, Urumqi, China.
- Publication Type:Journal Article
- MeSH:
Humans;
Suppressor of Cytokine Signaling 3 Protein;
Suppressor of Cytokine Signaling Proteins
- From:
Acta Academiae Medicinae Sinicae
2012;34(2):178-182
- CountryChina
- Language:Chinese
-
Abstract:
Suppressor of cytokine signaling(SOCS) 3, a novel type of cytokine signal transduction inhibitory molecules in family of SOCS, is mainly involved in Janus protein tyrosine kinase/signal transducer andantivator of transcription signaling pathway negative feedback regulation. It is involved in inflammation, oxidative stress, cell damage, and apoptosis. Meanwhile, it is closely related to atherosclerosis, obesity, glucose metabolism, insulin resistance, leptin, cancer, asthma, and rheumatic diseases. Therefore, SOCS-3 may become a therapeutic target of these diseases.
