Polycomb group proteins and their roles in regulating stem cell development.
10.3881/j.issn.1000-503X.2012.03.019
- Author:
Bing-yang HUANG
1
;
Xiao-yan PAN
;
Zhi-xin LI
;
Zheng-chao WANG
;
Yong-sheng YU
;
Zhao-hua DOU
Author Information
1. Department of Histology and Embryology, Jilin Medical College, Jilin 132013, China.
- Publication Type:Journal Article
- MeSH:
Cell Differentiation;
physiology;
Cell Proliferation;
Humans;
Polycomb Repressive Complex 1;
metabolism;
physiology;
Polycomb Repressive Complex 2;
metabolism;
physiology;
Polycomb-Group Proteins;
metabolism;
physiology;
Stem Cells;
cytology;
metabolism
- From:
Acta Academiae Medicinae Sinicae
2012;34(3):281-285
- CountryChina
- Language:English
-
Abstract:
Polycomb group (PcG) proteins are a family of epigenetic regulators responsible for the repression of genes in proliferation and differentiation of stem cells. PcG protein complex consists of two important epigenetic regulators: PRC1 (polycomb repressive complex 1) and PRC2 (polycomb repressive complex 2). In order to further understand the functions of PcG proteins in stem cell growth and differentiation, we review the PcG protein composition, PcG protein localization in the target gene, PcG protein recruitment, and the functions of PcG proteins in the development of stem cells.
