Molecular biology and clinical features of hereditary non-polyposis colorectal cancer.
10.3881/j.issn.1000-503X.2012.03.021
- Author:
Sha-sha GUAN
1
;
Guang-hai DAI
Author Information
1. Department of Multimodality Therapy Oncology, Chinese PLA Hospital, Beijing 100853, China.
- Publication Type:Journal Article
- MeSH:
Colorectal Neoplasms, Hereditary Nonpolyposis;
diagnosis;
genetics;
pathology;
DNA Mismatch Repair;
Humans;
Microsatellite Instability
- From:
Acta Academiae Medicinae Sinicae
2012;34(3):293-297
- CountryChina
- Language:English
-
Abstract:
Hereditary non-polyposis colorectal cancer (HNPCC) is an autosomal dominantly inherited disease associated with germ-line mutations in mismatch repair genes and microsatellite instability. This article reviews the molecular biology and clinical pathology of HNPCC.
