Abnormal liver function associated with polymorphism of GSTT1, GSTM1 and CYP2E1 in workers exposed to N, N-dimethylformamide.
- Author:
Cheng-Min XU
1
;
Ya-Ling QIAN
;
Li-Jin ZHU
;
Ju-Xiang XIAN
;
Jian-Rong CHAI
;
Zheng RUAN
;
Xing ZHANG
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Chemical and Drug Induced Liver Injury; etiology; genetics; Cytochrome P-450 CYP2E1; genetics; Dimethylformamide; adverse effects; Female; Genotype; Glutathione Transferase; genetics; Humans; Male; Occupational Exposure; adverse effects; Polymorphism, Genetic
- From: Chinese Journal of Industrial Hygiene and Occupational Diseases 2009;27(6):333-337
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate abnormal liver function associated with polymorphism of GSTT1, GSTM1 and CYP2E1 in workers exposed to N, N-dimethylformamide.
METHODSSixty-nine workers with abnormal liver function in a synthetic leather factory were recruited as case. One hundred and twenty five control subjects with similar work tasks were selected from the same factory. Genotypes for GSTT1 and GSTM1 were determined by multiplex PCR, and for CYP2E1 PstI by PCR-RFLP assay.
RESULTSThe frequency of positive GSTM1 was 59.42% in cases and 38.40% in control, with an odds ratio (OR) of 2.34,95% CI: 1.29-4.29 (P=0.005). For GSTT1 and CYP2E1 PstI, the frequencies of genotypes showed no significant difference between case and control.
CONCLUSIONGSTM1 positive genotype may be genetic risk factors for development of abnormal liver function in workers exposed to N, N-dimethylformamide.
