Effects of low concentration of chlorpyrifos prenatal exposure on generation mouse brain hippocampus and somatosensory cortex.
- Author:
Xiao-ping CHEN
1
;
Jian-long JIN
;
Chuan-wu LI
;
Fei-shi WANG
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Chlorpyrifos; toxicity; Female; Hippocampus; drug effects; pathology; Insecticides; toxicity; Male; Mice; Mice, Inbred ICR; Pregnancy; Prenatal Exposure Delayed Effects; Somatosensory Cortex; drug effects; pathology
- From: Chinese Journal of Industrial Hygiene and Occupational Diseases 2009;27(9):557-559
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo observe the effects of low concentration of organophosphate pesticide chlorpyrifos (CPF) prenatal exposure on generation mouse brain development.
METHODS5 mg/kg CPF was administered daily on gestation days (GD) 7.5 - 11.5. On postnatal day (PD) 35, quantitative morphologic examines were measured in CA1, CA3, dentate gyrus regions of the hippocampus and somatosensory cortex.
RESULTSAfter CPF prenatal exposure, selective morphology impairments were observed, showing 22.37%, 25.66% thinning of the CA1 and CA3 layers, 24.14% enlargement of the dentate guys and 81.77% to 74.61% decreasing of the ratio of neuron/glial of the somatosensory cortex.
CONCLUSIONThere maybe slight morphological changes after prenatal low concentration pesticide exposure even without obviously systemic toxicity.
