Injection of adenosine into the renal artery activates spontaneous activity of renal afferent nerve fibers.
- Author:
Hui-Jie MA
1
;
Hui-Juan MA
;
Yi-Xian LIU
;
Qing-Shan WANG
Author Information
1. Department of Physiology, Institute of Basic Medicine, Hebei Medical University, Shijiazhuang 050017.
- Publication Type:Journal Article
- MeSH:
Adenosine;
pharmacology;
Adenosine A1 Receptor Antagonists;
Afferent Pathways;
drug effects;
physiology;
Animals;
Dose-Response Relationship, Drug;
Electrophysiology;
Female;
Injections, Intra-Arterial;
Kidney;
innervation;
Male;
Nerve Fibers;
drug effects;
physiology;
Nitric Oxide;
physiology;
Rabbits;
Renal Artery;
Xanthines;
pharmacology
- From:
Acta Physiologica Sinica
2004;56(2):192-197
- CountryChina
- Language:English
-
Abstract:
The effects of injection of adenosine into the renal artery on multi- and single-unit spontaneous discharges of renal afferent nerve fibers were investigated in anesthetized rabbits. The results obtained are as follows: (1) injection of 50, 100, and 200 nmol/kg adenosine into the renal artery increased the renal afferent nerve activity (ARNA) in a dose-dependent manner with unchanged arterial pressure; (2) pretreatment with 8-cyclopenthl-1,3-dipropylxanthine (DPCPX, 160 nmol/kg), an adenosine A1 receptor antagonist, partly abolished the effect of adenosine; and (3) pretreatment with a nitric oxide synthase inhibitor N(omega)-nitro-L-arginine methylester (L-NAME, 0.1 mmol/kg) significantly enhanced the ARNA response to adenosine. The results suggest that injection of adenosine into the renal artery activates ARNA via adenosine receptors in anesthetized rabbits and that nitric oxide may be involved in regulating the activity of renal sensory nerve fibers as an inhibitory neurotransmitter.
