Baroreceptor reflex in heart failure.
- Author:
Wei WANG
1
;
Guo-Qing ZHU
;
Lie GAO
;
Wen TAN
;
Zhong-Ming QIAN
Author Information
1. Department of Physiology and Biophysics, University of Nebraska College of Medicine, Omaha, NE 68198-4575, USA. weiwang@unmc.edu
- Publication Type:Journal Article
- MeSH:
Angiotensin II;
metabolism;
Animals;
Baroreflex;
physiology;
Cardiac Output;
physiology;
Chemoreceptor Cells;
physiology;
Exercise;
physiology;
Heart Failure;
physiopathology;
Humans;
Reactive Oxygen Species;
metabolism;
Sympathetic Nervous System;
physiology;
Vascular Resistance;
physiology
- From:
Acta Physiologica Sinica
2004;56(3):269-281
- CountryChina
- Language:English
-
Abstract:
Congestive heart failure is a syndrome that is usually initiated by a reduction in pump function of the heart, i.e. a decrease in cardiac output. Initially, a reduction in cardiac output leads to unloading of baroreceptor reflex that, in turn, increases heart rate through vago-sympathetic mechanisms and total peripheral resistance via an increase in sympathetic outflow to vascular beds. In this review we are thinking on how baroreceptor reflex plays a role in the abnormal control of the circulation in heart failure. This review and our recent studies suggest that: (1) baroreceptor reflex is blunted in heart failure; (2) central angiotensin II and reactive oxygen species play an important role in blunted baroreceptor reflex; (3) cardiac sympathetic afferent stimulation and chemoreceptor reflex inhibit baroreceptor reflex; and (4) exercise training normalizes abnormal reflexes in the heart failure state.
