Different effects of 2 and 100 Hz tetanus on the expression of long-lasting long-term potentiation in rat visual cortical slices.
- Author:
Bin PAN
1
;
Dong-Wei YANG
;
Tai-Zhen HAN
Author Information
1. Department of Physiology, School of Medicine, Xi'an Jiaotong University, Xi'an, Shaanxi 710061, China.
- Publication Type:Journal Article
- MeSH:
Animals;
Electric Stimulation;
methods;
Long-Term Potentiation;
physiology;
Male;
Rats;
Rats, Sprague-Dawley;
Synaptic Transmission;
physiology;
Visual Cortex;
physiology
- From:
Acta Physiologica Sinica
2004;56(4):451-454
- CountryChina
- Language:English
-
Abstract:
Long-term potentiation (LTP) can be induced by various tetanic parameters in the mammalian visual cortex. However, little researches have been done on the relationship between the expression of the long-lasting LTP (late phase LTP or L-LTP) lasting more than 3 h and the tetanic parameters. In the present study, the effects of 2 Hz and 100 Hz tetanic parameters on L-LTP of the field potentials were recorded from the layer II/III of the rat visual cortical slices in response to stimulation of the layer IV. As a result, tetanic parameters that had more than 300 pulses reliably induced L-LTP in the postnatal day 15-21 rats. Obviously different L-LTP expressions were induced by 2 Hz and 100 Hz tetani. There was no difference in L-LTP expression induced by the parameters with the same frequency and different total pulses. These data suggest that L-LTPs induced by different frequency parameters may have different induction and maintenance mechanisms; L-LTPs induced by the parameters with the same frequency may have the same mechanisms.
