Changes of discharge rate and pattern of 5-hydroxytrypamine neurons of dorsal raphe nucleus in a rat model of Parkinson's disease.
- Author:
Yu-Xia CHU
1
;
Jian LIU
;
Jie FENG
;
Yong WANG
;
Qiao-Jun ZHANG
;
Qiang LI
Author Information
1. Department of Physiology, School of Medicine, Xi'an Jiao Tong University, Xi'an 710061, China.
- Publication Type:Journal Article
- MeSH:
Animals;
Electrophysiology;
Male;
Microelectrodes;
Neurons;
physiology;
Parkinson Disease;
physiopathology;
Raphe Nuclei;
metabolism;
physiopathology;
Rats;
Rats, Sprague-Dawley;
Serotonin;
metabolism
- From:
Acta Physiologica Sinica
2004;56(5):597-602
- CountryChina
- Language:Chinese
-
Abstract:
In the present study, changes of the neuronal activity of 5-hydroxytrypamine (5-HT) neurons of dorsal raphe nucleus(DRN) in a rat model of Parkinson's disease (PD) were investigated with glass microelectrode recording. The results showed that the discharge rates of 5-HT neurons in control and PD rats were (1.61+/-0.56) Hz and (2.61+/-1.97) Hz, respectively. The discharge rate of PD rats was significantly increased when compared to that of the control rats. In control rats, 79% of 5-HT neurons discharged regularly and 21% in bursts. In PD rats, however, 36% of 5-HT neurons discharged regularly, 16% irregularly and 47% in bursts. The percentage of 5-HT neurons discharging in bursts was obviously higher than that of the control rats (P<0.05). The data suggest that the discharge rate and bursting pattern of 5-HT neurons in DRN are increased in a rat model of Parkinson's disease.
