Comparative studies of vasodilating effects of angiotensin-(1-7) on the different vessels.
- Author:
Jian-Ming ZHI
1
;
Rong-Fang CHEN
;
Jin WANG
;
Xiang-Ying JIAO
;
Rong-Rui ZHAO
Author Information
1. Department of Physiology, Shanghai Second Medical University, Shanghai 200025, China. zhjm169@sohu.com
- Publication Type:Journal Article
- MeSH:
Angiotensin I;
pharmacology;
physiology;
Animals;
Endothelium, Vascular;
drug effects;
metabolism;
Female;
Male;
Nitric Oxide;
biosynthesis;
Peptide Fragments;
pharmacology;
Rabbits;
Receptor, Angiotensin, Type 1;
physiology;
Vasodilator Agents;
pharmacology
- From:
Acta Physiologica Sinica
2004;56(6):730-734
- CountryChina
- Language:English
-
Abstract:
The purpose of this study was to compare the vasodilating effects of angiotensin-(1-7) [Ang-(1-7)] on the different vessels and to clarify its mechanisms by using relaxing responses of preconstricted vascular rings. The results showed: (1) Ang-(1-7) dose-dependently induced vasorelaxation in all the vessels studied. However, there is apparent heterogeneity in the responsiveness of vessels from different origin. (2) The Ang-(1-7)-induced vasorelaxation was endothelium dependent and largely mediated by NO system. (3) The vasodilator action of Ang-(1-7) was not mediated by AT1 or AT2 receptor subtypes. It is suggested that the Ang-(1-7)-induced vasorelaxation is endothelium dependent by some other unclarified angiotensin receptor subtypes and is largely mediated by NO system.
