Study on protective effect of grape procyanidins in radiation injury in radiation-contacted persons.
- Author:
Jian-ying LIU
1
;
Jin-yi ZHONG
Author Information
- Publication Type:Journal Article
- MeSH: Cell Proliferation; Glutathione Peroxidase; blood; Humans; Leukocyte Count; Malondialdehyde; metabolism; Occupational Exposure; Placebos; Proanthocyanidins; pharmacology; Proliferating Cell Nuclear Antigen; biosynthesis; Radiation-Protective Agents; pharmacology; Superoxide Dismutase; blood; bcl-2-Associated X Protein; biosynthesis
- From: Chinese Journal of Preventive Medicine 2008;42(4):264-267
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the protective effect of Grape procyanidins (GPC) on radiation injury in radiation-contacted persons.
METHODSSixty radiation-contacted persons were randomly divided into the experimental group and the control group and 15 radiation-uncontacted persons were selected as the normal group. The experimental group was given GPC (100 mg/day), while the control group was given the capsule of starch every day for 60 days. Vein blood samples were taken before and after the study and the total antioxidative capacity (T-AOC), Malondialdehyde (MDA), cell proliferation, expression levels of proliferative cell nuclear antigen (PCNA), Bcl-2 and Bax protein, WBC were measured.
RESULTSThe WBC, T-AOC and cell proliferation rate of the experimental group were (5.62 +/- 0.40) 10(9)/L, (17.07 +/- 1.91) U/ml and 0.87 +/- 0.09 respectively, which were significantly higher than those of the control group. The MDA and Bax expression levels were (4.12 +/- 0.37) nmol/L and 28.06% +/- 5.79% respectively that were significantly lower than those of the control group.
CONCLUSIONGPC should have protective effects on radiation injury of the radiation-contacted persons.
