Etiologic fraction and interaction of risk factors for primary hepatic carcinoma in Guangxi, China.
- Author:
Sheng-Kui TAN
1
;
Xiao-Qiang QIU
;
Hong-Ping YU
;
Xiao-Yun ZENG
;
Zeng-Ming XIAO
;
Lang HU
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; Aged; Carcinoma, Hepatocellular; etiology; China; epidemiology; Data Interpretation, Statistical; Female; Humans; Liver Neoplasms; etiology; Male; Middle Aged; Risk Factors
- From: Chinese Journal of Preventive Medicine 2008;42(3):169-172
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore etiologic fraction (EF) and interaction of hepatitis B virus (HBV) infection and other risk factors for primary hepatocellular carcinoma (PHC) in Guangxi, China.
METHODSA hospital-based case-control study including 500 PHC patients and 500 nontumorous patients was carried out in Guangxi. EF and interactions of HBV infection and other risk factors for PHC were analyzed by crossover analysis and nonconditional multiple logistic regression.
RESULTSHBV infection, family history of PHC, diabetes mellitus, eating raw fish, heavy alcohol consumption, frequently used drug, low income, mental oppression and blood type B all were risk factors for PHC. With EFs of 0.725, 0.186, 0.119, 0.486, 0.385, 0.438, 0.277, 0.607, 0.299, respectively and with etiologic fractions attributable to interaction [EF(A xB)] of 0.736, 0.643, 0.849, 0.551, 0.592, 0.618, 0.902, 0.577; and indices of interaction of 0.743, 0.651, 0.853, 0.560, 0.600, 0.626, 0.907, 0.586, respectively.
CONCLUSIONMain risk factors for PHC might include HBV infection, family history of PHC, diabetes mellitus, eating raw fish, heavy alcohol consumption, frequently used drug, low income, mental oppression and blood type B. HBV infection with other risk factors might exert synergistic action on developing PHC and increase the risk of PHC.
