Association of genetic polymorphisms in selenoprotein GPX1 and TXNRD2 with genetic susceptibility of gastric cancer.
- Author:
Jia WANG
1
;
Tong SUN
;
Ming YANG
;
Dong-Xin LIN
;
Wen TAN
;
Ke-Ji LI
;
Ying XIAO
Author Information
- Publication Type:Journal Article
- MeSH: Alleles; Case-Control Studies; Female; Gene Frequency; Genetic Predisposition to Disease; Genotype; Glutathione Peroxidase; genetics; Humans; Male; Middle Aged; Polymorphism, Single Nucleotide; Stomach Neoplasms; genetics; Thioredoxin Reductase 2; genetics
- From: Chinese Journal of Preventive Medicine 2008;42(7):511-514
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVEThis study examined whether the two polymorphisms of GPX1 (198Pro--> Leu) and TXNRD2 (370Lys-->Arg) contributed alone or in combination, to the risk of gastric cancer development.
METHODSA total of 361 patients with gastric cancer and 363 cancer-free controls were recruited and their genotypes of the two polymorphisms were determined by polymerase chain reaction-based restrictive fragment length polymorphism (PCR-RFLP) method. Odds ratio (OR) and 95% confidence interval (CI) were computed using unconditional logistic regression model.
RESULTSGPX1 and TXNRD2 polymorphisms individually were not associated with the risk of gastric cancer. Gene-gene interaction of GPX1 and TXNRD2 polymorphisms decreased the risk of gastric cancer. Carrying the protective genotype might decrease the risk at 62% (OR = 0.38, 95% CI = 0.26-0.55, P < 0.001) as compared with the risk genotype.
CONCLUSIONThe GPX1 198 Pro/Pro and TXNRD2 370Arg/Arg genotypes might be associated with the genetic susceptibility of gastric cancer.
