Retrograde changes in the dorsal motor nuclei of rat vagus nerve after vagotomy.
- Author:
Haiyang ZHOU
1
;
Yetian CHANG
;
Ruping DAI
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Male; NADP; metabolism; Neurons; metabolism; Nitric Oxide Synthase Type II; metabolism; Rats; Rats, Sprague-Dawley; Vagotomy; Vagus Nerve; pathology; physiopathology; surgery
- From: Journal of Southern Medical University 2012;32(11):1576-1579
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the retrograde changes in the dorsal motor nuclei (DMV) of the vagus nerve after vagotomy in rats.
METHODSNissl staining and immunohistochemistry were used to observe the morphological and quantitative changes of the DMV and alterations of the expression of iNOS and NADPH after severing of the vagus nerve in adult male Wistar rats.
RESULTSCompared with the control group, the rats with right vagotomy showed obvious morphological changes and a significantly decreased number of neurons in the right DMV (P<0.05). Numerous iNOS- and NADPH-immunopositive cells were detected in the right DMV 5 and 10 days after right vagotomy.
CONCLUSIONVagotomy causes obvious retrograde changes in rat DMV shown by a significantly decreased number and obvious morphological changes of the neurons in the DMV.
