Expression of MDR1 gene in cancer stem cells in breast cancer tissues of different molecular subtypes.
- Author:
Guohua YANG
1
;
Fangqin XUE
;
Xiaogeng CHEN
Author Information
- Publication Type:Journal Article
- MeSH: ATP Binding Cassette Transporter, Sub-Family B; ATP-Binding Cassette, Sub-Family B, Member 1; genetics; metabolism; Adult; Breast Neoplasms; genetics; metabolism; Female; Humans; Middle Aged; Neoplastic Stem Cells; metabolism
- From: Journal of Southern Medical University 2012;32(11):1636-1638
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the association between MDR1 gene expression in breast cancer stem cells and the molecular subtypes of breast cancer tissue.
METHODSAccording to ER, PR, Her-2 and CK5/14 expression profiles, 153 breast cancer specimens were divided into 5 molecular molecular subtypes, in which the expression of MDR1 was detected to analyze the relationship between MDR1 gene expression and the subtypes of breast cancer stem cells.
RESULTSThe expression of MDR1 in Luminal A subtype breast cancer was 0.26∓0.04, which showed no significant difference from that of Luminal B subtype (0.31∓0.03, P>0.05). Compared with these two subtypes, HER-2 (+) subtype breast cancer tissues showed a significantly higher MDR1 expression(0.56∓0.05, P<0.05). MDR1 expression in Basal-like subtype and Normal-like subtype breast cancers was comparable (0.98∓0.01 vs 0.90∓0.15, P<0.05), but both significantly higher than that in Luminal A and B subtypes and HER-2 (+) subtype (P<0.05).
CONCLUSIONThe expression of MDR1 gene in cancer stem cells is related with the molecular subtypes of breast cancer tissue.
