Molecular mechanism of the sensitivity of myocardial cell injury after severe hypoxia.
- Author:
Shui-ming WANG
1
;
You-sheng LIU
;
Rui CHEN
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Cells, Cultured; Complement C3; metabolism; Gene Expression Profiling; Hypoxia; metabolism; Integrin beta Chains; metabolism; Mice; Muscle, Skeletal; metabolism; pathology; Myocytes, Cardiac; metabolism; pathology; Oligonucleotide Array Sequence Analysis; Proto-Oncogene Proteins c-bcl-2; metabolism; RNA, Messenger; metabolism; Rats; Vascular Cell Adhesion Molecule-1; metabolism
- From: Chinese Journal of Burns 2003;19(3):134-136
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the molecular mechanism of the sensitivity of myocardial cell injury after severe hypoxia.
METHODSDifferential expression of the genes in rat myocardium and skeletal muscles after severe hypoxia for 6 hours was determined by DNA chip containing 4096 mice genes.
RESULTSThere were high expressions of 125 genes in skeletal muscles and 111 genes in myocardial cells after 6 hours of severe hypoxia. Among them, high expression genes in myocardial cells included those encoding apoptosis activator Mtd, complement C3, vascular cell adhesion molecule-1, integrin beta subunit and lipopolysaccharide binding proteins (LBP).
CONCLUSIONActivation of apoptosis of myocardial cells and inflammatory mediators played important roles in myocardial cell injury after 6-hour severe hypoxia.
