Effects of medium and long-chain triglyceride on the immune function of burn patients during early postburn stage.
- Author:
Hong YAN
1
;
Xian-hui HUANG
;
Kang-ju XIAO
;
Xu-sheng LIU
;
Yi-zhi PENG
;
Yue-sheng HUANG
;
Shi-liang WANG
Author Information
- Publication Type:Clinical Trial
- MeSH: Adult; Burns; drug therapy; immunology; Dietary Proteins; therapeutic use; Dinoprostone; blood; Enteral Nutrition; Female; Humans; Interleukin-2; blood; Interleukin-4; blood; Lymphocyte Activation; Male; Time Factors; Triglycerides; therapeutic use
- From: Chinese Journal of Burns 2003;19(4):202-205
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the effects of medium and long-chain triglyceride on the immune function of burn patients during early postburn stage and its possible mechanism.
METHODSThirty burn patients with TBSA exceeding 30% were enrolled in this study and were randomly divided into two groups (n = 15 in each group). The patients in F group were supplemented orally with enteral nutrient Fresubin 750MCT containing medium (MCT) and long-chain triglyceride (LCT), and those in N group with Nutrition containing only LCT. All the patients were treated with nutritional support beginning from 24 PBH, continued for 10 days. The changes in plasma levels of IL-2, IL-4, PGE(2) and T lymphocyte transformation rate (LTR) in peripheral blood of patients in the two groups were determined on 1, 4, 7 and 10 postburn days (PBDs).
RESULTSThe plasma IL-2 level in all time points exhibited no difference in all patients (P > 0.05). The plasma level of PGE(2) on PBD 4 in F group was obviously lower than that in N group (P < 0.01). The plasma level of IL-4 on PBDs 4, 7 and 10 in F group were evidently higher than that in N group (P < 0.01). The T LTR in peripheral blood on PBDs 4 and 7 in F group was much higher than that in N group (P < 0.05 - 0.01).
CONCLUSIONEnteral nutrient containing MCT/LCT seemed to be superior to that containing only LCT in the improvement of postburn immune function in burn patients.