Isolation and analysis of the drug resistance of the flavobacterium and its production of beta-lactamases.
- Author:
Yu LUO
1
;
Pei-yuan XIA
;
Xian-yuan WANG
;
Chun-hong YIN
Author Information
- Publication Type:Journal Article
- MeSH: Anti-Bacterial Agents; pharmacology; Drug Resistance, Bacterial; drug effects; Flavobacterium; drug effects; enzymology; Humans; Membrane Proteins; analysis; metabolism; Microbial Sensitivity Tests; Ribosomal Proteins; analysis; metabolism
- From: Chinese Journal of Burns 2004;20(1):14-16
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the drug resistance of flavobacterium and its ability to produce BLA (beta-lactamases) and ESBLs (Extended-spectrum beta-lactamases).
METHODSThe production of BLA and ESBLs from 6 clinical isolated flavobacterium strains was determined by nitrocefin disc test and double-disc synergy method, respectively. The antibiotic susceptibilities of the strains were determined by Kirby-Bauer disc diffusion test and the agar dilution method and the MIC was assessed.
RESULTSAll the six flavobacteria were BLA-producing strains and more than 80% of them were ESBLs-producing, and they were highly resistant to beta-lactamase antibiotics (MIC 32 - 256 mg/L), but susceptible to fluoroquinolones and cephalosporin with beta-lactamase inhibitors (MIC 0.125 - 8 mg/L).
CONCLUSIONMost of the flavobacteria in nosocomial infections were beta-lactamase-producing and were highly resistant to beta-lactamase antibiotics. Fluoroquinolones and beta-lactamase antibiotics with lactamase inhibitors should be the first choice for the management of infection caused by flavobacterium.
