Distribution and expression of transforming growth factor beta and their receptors in hypertrophic scar.

Luo LU; Yu-lin Chen; Qing-guo Zhang

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Distribution and expression of transforming growth factor beta and their receptors in hypertrophic scar.

Author: Luo LU ¹ ; Yu-lin CHEN ; Qing-guo ZHANG
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1. Department of Burns, Changhai Hospital, Second Military Medical University, Shanghai 200433, P.R. China.
Publication Type:Journal Article
MeSH: Cicatrix, Hypertrophic; genetics; metabolism; Humans; Immunohistochemistry; In Situ Hybridization; RNA, Messenger; genetics; metabolism; Receptors, Transforming Growth Factor beta; genetics; metabolism; Skin; metabolism; pathology; Transforming Growth Factor beta; genetics; metabolism
From: Chinese Journal of Burns 2004;20(1):30-33
CountryChina
Language:Chinese
Abstract:
OBJECTIVETo explore the role of transforming growth factor beta (TGF beta) and their receptors (TGF beta-R) in the pathogenesis of hypertrophic scar.
METHODSSpecimens of normal skin and hypertrophic scar were harvested and the distribution and the expression of the TGF beta and TGF beta-R were determined by immunohistochemistry and in situ hybridization method.
RESULTSThe expressions of TGF beta and TGF beta-RII in normal skin were higher than the expression of TGF beta 1, TGF beta 2 and TGF-RI. But in hypertrophic scar the results were on the contrary. The mRNA expressions of TGF beta 1, TGF beta 2 and TGFRI were evidently increased with decreased mRNA expression of TGF-beta 3 and TGFR II in the hypertrophic scar when compared with those in the normal skin.
CONCLUSIONThe expression of TGF-beta (beta 1, beta 2, beta 3) and their receptors in different levels during the process of wound healing might be related to the formation of hypertrophic scars.