Comparison of the Intraocular Pressure Reducing E ffect of Latanoprost with Timolol.
- Author:
Hyo LEE
1
;
Chan Yoon KIM
;
Ho Kyum KIM
;
Young Jae HONG
Author Information
1. The Institute of Vision Research, College of Medicine, Yonsei University, Seoul, Korea.
- Publication Type:Original Article ; Randomized Controlled Trial
- Keywords:
Glaucoma;
Intraocular pressure;
Latanoprost;
Timolol
- MeSH:
Follow-Up Studies;
Glaucoma;
Glaucoma, Open-Angle;
Humans;
Hyperemia;
Hyperpigmentation;
Intraocular Pressure*;
Iris;
Ocular Hypertension;
Timolol*
- From:Journal of the Korean Ophthalmological Society
2000;41(2):459-468
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
We compared the intraocular pressure reducing effect and side effects of 0.005%Latanoprost administered once daily with 0.5%Timolol administered twice daily in patients with open-angle glaucoma or ocular hypertension. This was an open randomized study with two parallel groups and a treatment period of 12 weeks. A total of 76 patients were included:38 in the Latanoprost group and 38 in the Timolol group. Intraocular pressure was reduced from 25.92 mms of mercury to 17.12 mms of mercury[33.91%]with Latanoprost and from 22.53 mms of mercury to 18.38 mms of mercury[18.42%]with Timolol. The efficacy of Latanoprost was statistically superior to timolol[p<0.001]. Latanoprost induced a slight conjunctival hyperemia and ocular discomfort but both drugs were generally well tolerated. Iris hyperpigmentation reported as a significant side effect of Latanoprost was not observed during 12 weeks of follow-up. It is concluded that Latanoprost administered once daily in the evening reduced intraocular pressure as well as and probably more than Timolol administered twice daily.
