Study of the preparation of silk fibroin gel and its morphology as drug release matrix in vitro and in vivo.
- Author:
Qing LI
1
;
Jie HUANG
;
Fei HE
;
Qingmei HE
;
Chuanbao CAO
;
Song WANG
Author Information
1. Material Science, School of Materials and Engineering, Beijing Institute of Technology, Beijing 100081, China.
- Publication Type:Journal Article
- MeSH:
Alginates;
chemical synthesis;
chemistry;
Animals;
Biocompatible Materials;
chemical synthesis;
Delayed-Action Preparations;
chemistry;
Drug Carriers;
chemical synthesis;
chemistry;
Extracellular Matrix;
chemistry;
Fibroins;
chemical synthesis;
chemistry;
Glucuronic Acid;
chemical synthesis;
chemistry;
Hexuronic Acids;
chemical synthesis;
chemistry;
Hydrogels;
chemical synthesis;
chemistry;
Myocardium;
chemistry;
Rats;
Swine;
Tissue Extracts;
chemistry
- From:
Journal of Biomedical Engineering
2013;30(4):794-811
- CountryChina
- Language:Chinese
-
Abstract:
Silk fibroin (SF)/sodium alginate (SA) hydrogels can be used as drug injection materials. Homogenate was prepared by centrifugation of the pig myocardial extracellular matrix (PMM) and its modification of SF gel material. This paper observes and compares the different components SF, SF/SA, SF/SA/PMM to illustrate the SF/SA/PMM ternary material as a drug delivery composition material. This ternary material can shorten the gel time, and can make the gel form to be maintained better. Meanwhile, it makes the internal structure of the gel looser so that the hole wall becomes thinner and more conducive to the drug release. In addition, it has good biocompatibility proved by pathological analysis, and is able to enhance the mesenchymal stem cells growth activity, which has great significance in carrying out drug control release.
