Cytogenetic and clinical characteristics in 31 cases of blood diseases with aberrations at short arm of chromosome 12.
- Author:
Yan ZHANG
1
;
Jing-Ying QIU
;
Qi HE
;
Yan SHI
;
Dao-Pei LU
Author Information
1. Institute of Hematology and People's Hospital, Peking University, Beijing 100044, China.
- Publication Type:Journal Article
- MeSH:
Adolescent;
Adult;
Aged;
Child;
Chromosome Aberrations;
Chromosomes, Human, Pair 12;
Female;
Humans;
Leukemia;
genetics;
Male;
Middle Aged;
Multiple Myeloma;
genetics;
Myelodysplastic Syndromes;
genetics
- From:
Journal of Experimental Hematology
2004;12(2):166-169
- CountryChina
- Language:Chinese
-
Abstract:
To investigate the cytogenetic and clinical characteristics in patients with abnormalities at the short arm of chromosome 12, chromosome specimens were prepared by 24-hour culture of bone marrow cells and undergone karyotype analysis by G-banding technique. The results showed that aberration at the short arm of chromosome 12 were detected in 16 cases with 12p balanced translocation, in 10 cases with 12p deletion, 6 cases with 12p addition, and in 1 case with inversion 12. By complex karyotype classification, 12p translocation included 6 simple aberrations, 6 complex aberrations, and 4 highly complex aberrations; while 12p deletion were mainly composed of highly complexity of aberration. Patients consisted of acute leukemia, myelodysplastic syndrome, chronic myelogenous leukemia and so on. Clinical follow-up data were available in 14 patients, in which 8 cases of acute leukemia were treated with conventional chemotherapy only. Three of them attained complete remission, and the median survival time in 8 patients was 5.5 months. In conclusion, the aberrations at short arm of chromosome 12 were involved in a broad spectrum of haematological malignancies, and the karyotypes showed most complexity of aberration with low remission rate and short survival in clinic.
