The diagnostic value of platelet glycoprotein-specific autoantibody detection in idiopathic thrombocytopenic purpura.
- Author:
Hai-Yan ZHANG
1
;
Ming HOU
;
Xiao-Hong ZHANG
;
Xiang-Hong GUAN
;
Gui-Zhen SUN
Author Information
1. Department of Hematology, Linyi People Hospital, Linyi 276003, China.
- Publication Type:Journal Article
- MeSH:
Adolescent;
Adult;
Aged;
Autoantibodies;
blood;
Child;
Female;
Humans;
Male;
Middle Aged;
Platelet Membrane Glycoproteins;
immunology;
Purpura, Thrombocytopenic, Idiopathic;
diagnosis;
immunology;
Sensitivity and Specificity
- From:
Journal of Experimental Hematology
2004;12(2):204-206
- CountryChina
- Language:Chinese
-
Abstract:
To detect levels of platelet glycoprotein-specific autoantibody in idiopathic thrombocytopenic purpura (ITP), chronic aplastic anemia (CAA), hematologic malignancies and healthy volunteers, and evaluate the clinical significance of platelet glycoprotein-specific autoantibody level in diagnosis for ITP, anti-GPIb/IX, anti-GPIIb/IIIa, anti-GPIV and anti-GPV auto-antibodies were detected contemporaneously by a modified monoclonal antibody immobilization of platelet antigen assay (modified MAIPA). The results showed that the total positive rate of antibodies against platelet GPIb/IX, GPIIb/IIIa, GPIV, GPV were 69.99%, 10%, 20% and 0% in ITP, CAA, hematologic malignancy group and healthy volunteers respectively. There was significant difference between ITP and CAA (chi(2) = 20.71, P < 0.005), between ITP and hematologic malignancy group (chi(2) = 12.22, P < 0. 005). There was no positive finding in the healthy control. It is concluded that platelet glycoprotein-specific autoantibody has high value for the diagnosis of ITP,many kinds of antibodies detection at one time can enhance sensitivity, MAIPA is a specific assay for the diagnosis of idiopathic thrombocytopenic purpura.
