Special morphological changes of pathologic cells in two cases of Waldenström's macroglobulinemia.
- Author:
Xue-Liang CHEN
1
;
Fang-Lin LI
;
Chuan-Li ZHAO
;
Dao-Zi JIANG
;
Ping QIN
;
Ying-Fu WANG
;
Shu-Xin YAN
Author Information
1. Department of Hematology, Tumor Center of Qilu Hospital, Shandong University, Jinan 250012, China. xlchen1999@yahoo.com
- Publication Type:Case Reports
- MeSH:
Adult;
Humans;
Male;
Middle Aged;
Waldenstrom Macroglobulinemia;
pathology
- From:
Journal of Experimental Hematology
2004;12(2):220-223
- CountryChina
- Language:Chinese
-
Abstract:
Waldenström's macroglobulinemia (WM) is one of malignant hematological disease on account of abnormal proliferation of B lymphocyte clone and the pathologic cells of WM possess ability to secrete monoclonal immunoglobulin M. In this study, the diagnosis and morphological characteristics of 2 patients with WM were analyzed. The results showed that a special kind of "foam cells" were found by cytochemical staining examinations in both cases, which displayed characteristics of lymphocytes, but neither monocyte-macrophage nor fatty cells. The periodic acid-Shiff's reaction (PAS) demonstrated strong positive, especially on the inclusion bodies in pathologic cell plasma while the acid phosphatase, and alpha-butanoic acetate esterase stainings, resulted both in negative. In conclusion, the cells found in the two cases reported may be described as gemmy ring-like lymphocyte in morphology, a special subtype of ring-like lymphocyte.
