Tumor antigen-specific cytotoxic T lymphocytes and cancer immunotherapy - review.
- Author:
Ying LIU
1
Author Information
1. Department of Pediatric Internal Medicine, General Hospital of PLA, Beijing 100853, China.
- Publication Type:Journal Article
- MeSH:
Animals;
Antigens, Neoplasm;
immunology;
Cancer Vaccines;
immunology;
Humans;
Immunotherapy;
Neoplasms;
immunology;
therapy;
T-Lymphocytes, Cytotoxic;
immunology
- From:
Journal of Experimental Hematology
2004;12(2):244-248
- CountryChina
- Language:Chinese
-
Abstract:
Tumor antigen-specific cytotoxic T lymphocytes are important anti-cancer cells. The focuses of this review are to introduce the molecular basis of antigen presentation and CTL recognition, to summarize the identification of tumor associated antigens and their T cell epitopes, to highlight the current insights into the immunogenicity of TAA peptides and the principles of peptide-based vaccines against cancer, and to comment on future prospects for CTL therapy.
