Progress of studies on enhancing efficiency of gene transfection into hematopoietic cells with the adenoviral vector--review.
- Author:
Li-Sha WANG
1
;
Hai-Feng DUAN
;
Li-Sheng WANG
Author Information
1. Institute of Radiation Medicine, Academy of Military Medical Sciences, Beijing 100850, China.
- Publication Type:Journal Article
- MeSH:
Adenoviridae;
genetics;
Coxsackie and Adenovirus Receptor-Like Membrane Protein;
Genetic Therapy;
Hematopoietic Stem Cells;
metabolism;
Humans;
Receptors, Virus;
genetics;
Transfection
- From:
Journal of Experimental Hematology
2004;12(3):383-386
- CountryChina
- Language:Chinese
-
Abstract:
Recombinant adenoviral vectors have been widely applied for the basic research and clinical trials of gene therapy. However, the inability of adenovirus to infect hematopoietic cells which lack the specific adenovirus receptors-coxsackie virus and adenovirus receptor (CAR) represents an important limitation in therapeutic applications. This limitation may be overcome by several approaches including modification of adenovirus vector and improvement of the susceptibility of hematopoietic cells. The current progresses in this field were summarized.
