Clinical studies on expressions of Fas and mdr-1 in acute leukemia and their correlations.
- Author:
Fang YE
1
;
Zhen-Hua QIAO
;
Li-Ping SU
;
Liang-Ming MA
;
Lei ZHU
;
Li ZHANG
Author Information
1. Department of Hematology, The Second Hospital of Shanxi Medical University, Taiyuan 030001, China.
- Publication Type:Journal Article
- MeSH:
Adolescent;
Adult;
Aged;
Child;
Drug Resistance, Multiple;
Drug Resistance, Neoplasm;
Genes, MDR;
Humans;
Leukemia, Myeloid, Acute;
drug therapy;
metabolism;
mortality;
Middle Aged;
Precursor Cell Lymphoblastic Leukemia-Lymphoma;
drug therapy;
metabolism;
mortality;
RNA, Messenger;
analysis;
fas Receptor;
analysis
- From:
Journal of Experimental Hematology
2004;12(4):411-415
- CountryChina
- Language:Chinese
-
Abstract:
To explore the Fas and mdr-1 expression and their correlation in multidrug resistance (MDR), Fas and mdr-1 expressions of bone marrow from 59 patients with newly diagnosed AL before therapy and after complete remission were detected by direct immunofluorescence with flow cytometry and semi-quantitative RT-PCR, respectively. The results showed that in newly diagnosed AL patients, Fas expression in AML was higher than in ALL (P < 0.05), mdr-1 expression in AML and ALL had no difference (P > 0.05), the expressions of Fas and mdr-1 had correlation (r = -0.282, P < 0.05) in AL; the results of simple-variable and multivariable COX survival factor model analysis suggested that Fas and mdr-1 expressions were prognostic factors for the effect of therapy and survival. Log rank test, comparing the groups of Fas(+) with Fas(-), mdr-1(+) with mdr-1(-), demonstrated that the CR rates and median remission time of every two groups had significant difference. It is concluded that in AL, Fas and mdr-1 expressions have high correlation with the effect of treatment, Fas expression probably is one of the favorable prognostic factors, mdr-1 is an unfavorable prognostic and less effective factor.
