Recent advance on LFA-1/ICAM-1 costimulatory signal of T cell-review.
- Author:
Wen-Rong HUANG
1
;
Li-Sheng WANG
;
Wan-Ming DA
Author Information
1. Department of Hematology, General Hospital of PLA, Beijing 100853.
- Publication Type:Journal Article
- MeSH:
Animals;
Cytokines;
biosynthesis;
Cytotoxicity, Immunologic;
Humans;
Intercellular Adhesion Molecule-1;
physiology;
Lymphocyte Activation;
Lymphocyte Function-Associated Antigen-1;
physiology;
Signal Transduction;
T-Lymphocytes;
immunology
- From:
Journal of Experimental Hematology
2004;12(4):533-537
- CountryChina
- Language:Chinese
-
Abstract:
LFA-1/ICAM-1 costimulation plays an important role in immunologic reaction of many different T cell populations. After TCR/CD3 complex cross-linking MHC/peptide, LFA-1, expressed on T cell increases a higher affinity and avidity for ICAM-1 rapidly. LFA-1 is a key molecule in formation of the immune synapse. LFA-1/ICAM-1 costimulation can engage various signaling events of T cell by up-regulating the activities of PI 3-kinase, sphingomyelinase, and c-Jun NH2-terminal kinase. With the costimulation of LFA-1/ICAM-1, engagement of TCR molecules results in a significant increase of T cell activities, including higher Th1 cytokines production, strongly proliferative response and higher T cell cytotoxicity.
