BACKGROUNDTo evaluate the relationship among indoor air pollution, depression and oncogenesis of lung cancer.

METHODSAn 1:3 matched case-control study was carried out. Conditional logistic regression was applied to process the data.

RESULTSAfter some confounding factors were adjusted, the ORs increased 122% and 113% for the amount of coal using ≥46kg/m² and heating by coal stove respectively. The ORs elevated more than five-folds for disharmony and rupture of marriage, difference of accommodation and acclimation by oneself and human relationship respectively. The risk of lung caner obviously increased for frequent exposure to indoor cooking smoke combinated with depressed mood or mental scar respectively.

CONCLUSIONSThe indoor air pollution, depression and mental scar are important factors of oncogenesis of lung cancer.