PCR-SSCP analysis of nm23 gene mutation in non-small cell lung cancer.
- Author:
Haifeng WANG
1
;
Xiaofeng CHEN
;
Wen GAO
;
Jiaan DING
;
Xianghua YI
Author Information
- Publication Type:Journal Article
- From: Chinese Journal of Lung Cancer 2002;5(3):167-169
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUNDTo investigate the role of nm23 gene mutation in human non small cell lung cancer (NSCLC).
METHODSThe mutation of nm23 gene was detected in 53 primary NSCLC tissues and 5 cases of other pulmonary benign or malignant disease tissues by PCR SSCP.
RESULTSNo mutation of nm23 gene was found in all 58 specimens.
CONCLUSIONSThe mutation of the nm23 gene may not effectively forebode the aggressiveness and metastatic potential of NSCLC.
