A study on the expression of erbB4/HER4 in non-small cell lung cancer.

Author: Zaichun DENG ¹ ; Wenying YU ; Guoping HU ; Ruheng ZHENG ; Dunhua ZHANG ; Yunshan TAN ; Yonghua XU ; Wanli JIANG
Author Information

1. Respiratory Department, The Affiliated Hospital, Ningbo University, Ningbo, Zhejiang 315020, P.R.China.
Publication Type:Journal Article
From: Chinese Journal of Lung Cancer 2002;5(3):177-179
CountryChina
Language:Chinese
Abstract:
BACKGROUNDTo detect the expression of human epidermal-growth-factor receptor 4 (HER4) and elucidate the relationship between its overexpression and the clinicopathological characteristics in non-small cell lung cancer (NSCLC).
METHODSThe expression of HER4 was detected in 70 cases of paraffin-embedded NSCLC tissues by immunohistochemical assay.
RESULTSHER4 were overexpressed in 91.4% of NSCLC. The overexpression of HER4 was significantly related to lymph node metastasis (P=0.007), TNM stages (P=0.011) and postoperative survival rate (P= 0.0258).
CONCLUSIONSerbB4 is one of the genes to regulate the growth of advanced NSCLC. The artificial interference with HER4 overexpression may be a good way in the treatment of advanced NSCLC.