Effects of acupuncture on granulocyte apoptosis and expressions of apoptosis-associated genes in the ovary of perimenopausal rats.
- Author:
Xiao-peng MA
1
;
Ming DAI
;
Huan-gan WU
;
Zheng SHI
;
Cui-ying ZHAO
;
Xian HONG
Author Information
- Publication Type:Journal Article
- MeSH: Acupuncture Therapy; Animals; Apoptosis; Female; Granulocytes; pathology; Ovary; metabolism; pathology; Perimenopause; Proto-Oncogene Proteins c-bcl-2; analysis; Rats; Rats, Sprague-Dawley; fas Receptor; analysis
- From: Chinese Acupuncture & Moxibustion 2007;27(5):357-361
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the mechanism of acupuncture for treatment of perimenopausal syndrome.
METHODSThe rats of perimenopausal syndrome were randomly divided into 3 groups, including an acupuncture group treated with acupuncture, a medication group with Gengnian'an, and a perimenopausal control group, with young rats used for a control group. Granulocyte apoptosis and expressions of Bcl-2 and Fas proteins in the ovary of the rat were detected.
RESULTSGranulocyte apoptosis increased significantly (P < 0.01), expression of Bl-2 proteins decreased significantly (P < 0.01) and expression of Fas proteins increased significantly (P < 0.01) in the ovary of perimenopausal rats as compared with the young rats; after acupuncture treatment, granulocyte apoptosis decreased significantly (P < 0.05), expression of Bel-2 proteins increased significantly (P < 0.05) and expression of Fas proteins decreased significantly (P < 0.01); after treatment of Gengnian'an, granulocyte apoptosis did not significantly change (P > 0.05), expression of Bcl-2 prteins increased significantly (P < 0.05) and expression of Fas proteins decreased significantly (P < 0.01).
CONCLUSIONAcupuncture can inhibit granulocyte apoptosis, up-regulate expression of Bcl-2 proteins and down-regulate expression of Fas proteins in the ovary of the perimenopausal rat.
