Experimental studies on hepatotoxicity of rats induced by Fructus Gardeniae.
- Author:
Hong-jun YANG
1
;
Mei-hong FU
;
Zi-lun WU
;
Ri-xing LIANG
;
Lu-qi HUANG
;
Jing FANG
;
Geng LI
;
Ying CAO
Author Information
- Publication Type:Journal Article
- MeSH: Alanine Transaminase; blood; Animals; Aspartate Aminotransferases; blood; Bilirubin; blood; Drugs, Chinese Herbal; isolation & purification; toxicity; Female; Fruit; chemistry; Gardenia; chemistry; Iridoids; isolation & purification; toxicity; Liver; pathology; Male; Organ Size; drug effects; Plants, Medicinal; chemistry; Pyrans; isolation & purification; toxicity; Random Allocation; Rats; Rats, Sprague-Dawley
- From: China Journal of Chinese Materia Medica 2006;31(13):1091-1093
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the hepatotoxicity effects in rats with different extract of Fructus Gardeniae.
METHODObserve the change of appearance, behavior and weight of rats through oral gavage daily for 3 d. Weigh the liver and calculate the liver index. Detect the ALT, AST and TBIL. Observe the liver tissue by optical microscope.
RESULTThe weight and index of liver were increased by 3.08 g x kg(-1) aqueous extract, 1.62 g x kg(-1) alcoholic extract and 0.28 g x kg(-1) geniposide, compared to those of the blank group (P < 0.005, P < 0.001) and the activities of ALT, AST and the content of TBIL were also increased, compared to those of the blank group (P < 0.05, P < 0.001). The liver cells were obviously swell, necrotic and changed with inflammatory infiltrate.
CONCLUSIONAqueous extract, alcoholic extract and geniposide displayed hepatotoxicity, and the geniposide which was the main substance of the Fructus Gardeniae might be mainly responsible for the hepatotoxicity.
