Influence of Hovenia dulcis on alcohol concentration in blood and activity of alcohol dehydrogenase (ADH) of animals after drinking.
- Author:
Shao-hong CHEN
1
;
Gan-sheng ZHONG
;
Ai-li LI
;
Shao-hua LI
;
Li-kun WU
Author Information
- Publication Type:Journal Article
- MeSH: Alcohol Dehydrogenase; metabolism; Animals; Drugs, Chinese Herbal; isolation & purification; pharmacology; Ethanol; blood; toxicity; Liver; enzymology; Male; Mice; Mice, Inbred ICR; Plants, Medicinal; chemistry; Random Allocation; Rhamnaceae; chemistry; Seeds; chemistry
- From: China Journal of Chinese Materia Medica 2006;31(13):1094-1096
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo observe the effects of H. dulcis on relieving alcohol toxicity by animal experiments.
METHODMale kunming mice were ovraiectomized and randomly divided into 5 groups: control group, model group, and aqueous extracts of H. dulcis group at 0.5, 0.25, 0.125 g x mL(-1). The acute alcohlism animals induced by gastral administration with "Er Guo Tou" and the alchol concentrations in serum were detected after treated with the extracts within 0.5-3 h by biochemical enzymes.
RESULTThe alcohol concentration in blood was up to the maximum in 0.5-1.5 h. However, the alcohol concentrations in blood of aqueous extract from H. dulcis group were decreased in 0.5-3 h. The activity of ADH in the liver in aqueous extract of H. dulcis group was increased in 2-3 h, while it was significantly increased in 1-1.5 h (P <0.05).
CONCLUSIONThe aqueous extract of H. dulcis could reduce the alchol concentration in blood of animals and inrease the activity of ADH after given alcohol. It means the extract has the effect of relieving alcohol toxicity and preventing drunkenness through restraining the absorption of alcohol in the gastrointestinal tract and promoting the metabolism of alcohol in the liver.
