Effect of Kunyining capsule on reproductive endocrine-immune functions in ovariectomized rats.
- Author:
Ming-hua YANG
1
;
Su-bei YANG
;
Sen LONG
;
Zu-han JIN
;
Jie JIN
Author Information
- Publication Type:Journal Article
- MeSH: Adrenal Glands; drug effects; Animals; Body Weight; drug effects; Capsules; Drug Combinations; Drugs, Chinese Herbal; administration & dosage; isolation & purification; pharmacology; Estradiol; blood; Female; Follicle Stimulating Hormone; blood; Interleukin-2; blood; Luteinizing Hormone; blood; Organ Size; drug effects; Osteocalcin; blood; Ovariectomy; Plants, Medicinal; chemistry; Prolactin; blood; Random Allocation; Rats; Rats, Sprague-Dawley; Uterus; drug effects
- From: China Journal of Chinese Materia Medica 2006;31(13):1107-1109
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the therapeutic mechanism of Kunyining (KYN) on the climacteric syndrome and provide the pharmacodynamic basis.
METHODOvariectomized rats were used as model to observe the effect of KYN on weight and the index of the organ of OVX rats. The concentration of E2, FSH, LH, PRL, BGP and IL-2 in serum were measured by competitive radio-immunological methods.
RESULTKYN could obviously increase the index of uterus and adrenal gland in OVX rats, and enhance the contents of E2, IL-2 and BGP. The level of FSH, LH, PRL in serum were decreased.
CONCLUSIONKYN can regulate beneficially the unbalanced reproductive endocrine-immune network, which is the pharmacological basis of KYN treating climacteric syndrome.
