Solubilities of ephedrine and d-pseudo-ephedrine from different sizes of ultramicro-particles of the compound traditional Chinese herbs Maxing Shigan decoction.
- Author:
Nan SI
1
;
Jian YANG
;
Bao-lin BIAN
Author Information
- Publication Type:Journal Article
- MeSH: Calcium Sulfate; chemistry; Drug Combinations; Drugs, Chinese Herbal; administration & dosage; chemistry; isolation & purification; Ephedra; chemistry; Ephedrine; analysis; chemistry; Glycyrrhiza uralensis; chemistry; Particle Size; Plants, Medicinal; chemistry; Powders; Prunus; chemistry; Solubility; Technology, Pharmaceutical; methods
- From: China Journal of Chinese Materia Medica 2006;31(11):884-886
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo compare the solubilities of ephedrine and d-pseudo-ephdrine in the compound of traditional Chinese drugs--Maxing Shigan decoction with and without ultramicro-pulverizations using a RP-HPLC procedure.
METHODThe analytical column was a YMC ODS-C18(4.6 mm x 150 mm,4 microm). A mixture of water-acetonitrile-sodium dodecyl sulfate-phosphorous acid (650:350:5:1) was used as the mobile phase at flow rate of 1.5 mL x min(-1). The column temperature was 50 degrees C and the wavelength was 210 nm.
RESULTIn this way, ephedrine and d-pseudo-ephedrine of the compound samples can be separated well and showed significant differences before and after the ultramicro-pulverizations.
CONCLUSIONFor the Maxing Shigan decoction, the dissolution rates and solubilites of ephedrine and d-pseudo-ephedrine ultramicro-pulverization were greatly improved.
