Bioactive isomalabaricane triterpenes isolated from marine sponge Rhabdastrella aff. distincta.
- Author:
Fang LU
1
;
Wen-han LIN
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Antineoplastic Agents; isolation & purification; pharmacology; HL-60 Cells; drug effects; HeLa Cells; drug effects; Humans; Materia Medica; isolation & purification; pharmacology; Porifera; chemistry; Resorcinols; isolation & purification; pharmacology; Triterpenes; isolation & purification; pharmacology; Tumor Cells, Cultured; drug effects
- From: China Journal of Chinese Materia Medica 2006;31(11):894-898
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the chemical constituents of the marine sponge Rhabdastrella aff. distincta.
METHODCompounds were obtained by normal phase silica gel, Sephadex LH-20, reverse phase chromatogrophy and methylation method. These structures were determined on the basis of IR, MS, NMR spectral analysis.
RESULTEight compounds were isolated from bioactive CH3Cl fraction and identified as geoditin A (1), geoditin B (2), stellettin A (5), stellettin B (4), stellettin C (3), stellettinE (7), rhabdastrellic acid A (8) and the methyl ester of stellettin E (6).
CONCLUSIONAll these compounds were obtained from this species for the first time.
