Preparation and in vitro evaluations of topically applied capsaicin transfersomes.
- Author:
Xiao-ying LONG
1
;
Jia-bo LUO
;
Li-ren LI
;
Dan LIN
;
Hui-si RONG
;
Wei-min HUANG
Author Information
- Publication Type:Journal Article
- MeSH: Administration, Cutaneous; Analgesics, Non-Narcotic; administration & dosage; pharmacokinetics; Animals; Capsaicin; administration & dosage; pharmacokinetics; Drug Carriers; Drug Delivery Systems; methods; Humans; In Vitro Techniques; Male; Mice; Particle Size; Phosphatidylcholines; administration & dosage; chemistry; pharmacology; Rats; Skin; drug effects; metabolism; Skin Absorption; drug effects
- From: China Journal of Chinese Materia Medica 2006;31(12):981-984
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVECapsaicin transfersomes were prepared and its quality specifications were evaluated.
METHODCapsaicin transfersomes were prepared by high shear dispersing machine and evaluated on the entrapment efficiency, drugs release rate and in vitro skin permeation.
RESULTCapsaicin transfersomes is composed of single unilamellar vesicles, with average size of 150.6 nm. Capsaicin entrapment efficiency achieved 96.7% while concentration of lecithin used was 8%. cumulative release amount of capsaicin was in direct proportion to the ethanol concentration in the medium. The in vitro rate cumulative penetration rate of capsaicin was higher in transfersomes than in cream and suspension in rats. Adomen skin cumulative penetration rate in vitro of capsaicin transfersomes in mouse was significantly higher than that from rat and men. In the same way,cumulative penetration rate in vitro of capsaicin transfersomes through abdomen skin epidermal membrance was significantly higher than that with derma and full skin in men.
CONCLUSIONEntrapment efficiency of capsaicin transfersomes reached 96.7%, meeting the criterion of China pharmacopia( > 80%), skin penetration of capsaicin was enhanced by a capsaicin transfersomes preparation and was affected by diverse characters and levels of skin.
