Studies on the absorption kinetics of baicalin and baicalein in rats' stomachs and intestines.
- Author:
Tai-ming LIU
1
;
Xue-hua JIANG
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Colon; metabolism; Duodenum; metabolism; Flavanones; isolation & purification; pharmacokinetics; Flavonoids; isolation & purification; pharmacokinetics; Ileum; metabolism; Intestinal Absorption; Intestines; metabolism; Jejunum; metabolism; Male; Plants, Medicinal; chemistry; Rats; Rats, Wistar; Scutellaria; chemistry; Stomach; metabolism
- From: China Journal of Chinese Materia Medica 2006;31(12):999-1001
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the absorption kinetics of baicalin and baicalein in rats' stomachs and intestines.
METHODThe drug concentration by in situ perfusion in rats were determined by HPLC.
RESULTThe hourly absorption percentages of baicalin in stomach, small intestine and colon were 8.05%, - 0.94% and 2.32%, respectively, and baioalein with 34.53%, 30.61% and 4.89%, respectively. The absorption rate constants of baicalein were 0.090 7, 0.083 7, 0.076 6 and 0.048 3, respectively in duodenum, jejunum, ileum and colon.
CONCLUSIONBaicalin is moderately absorbed in stomach and poorly in small intestine and colon; Baicalein is well absorbed in stomach and small intestine but worse in colon, suggesting that the former is more suitable to be administered orally. The extensive absorption segments of bacailein suggests that it can be processed into a sustained-release preparation.
