Renal protective effect of Shenkang pill on diabetic rats.
- Author:
Wei XIAO
1
;
Lian-Bo WEI
;
Yun MA
;
Hai-Bo LONG
;
Guo-Bao CHEN
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Blood Glucose; metabolism; Blood Urea Nitrogen; Diabetic Nephropathies; chemically induced; metabolism; pathology; Drug Combinations; Drugs, Chinese Herbal; isolation & purification; pharmacology; Fibronectins; biosynthesis; genetics; Glycated Hemoglobin A; metabolism; Kidney; metabolism; Male; Plants, Medicinal; chemistry; RNA, Messenger; biosynthesis; genetics; Random Allocation; Rats; Rats, Wistar; Streptozocin
- From: China Journal of Chinese Materia Medica 2006;31(12):1006-1009
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the effects of Shenkang pill on renal function and extracellular matrix secretion on the diabetic rats.
METHODThe diabetic rat models were induced by intraperitoneal injection of streptozotocin (STZ) and randomly divided into 3 groups' model control group; Capoten group and Shenkangwan group. Some normal other rats were used as normal control group. All rats were treated with corresponding drugs for 8 weeks. During and after the treatment, the general state, blood and urine glucose levels, excretion rate of the 24 hour urine protein and albumin, serum creatinine and blood urea nitrogen contents, kidney weight and relative kidney weight were measured. The mRNA of fibronectin(FN) in the kidney also detected by semi-quantitative reverse transcription polymerase chain reaction(RT-PCR).
RESULTDiabetes mellitus and renal lesions occurred in the three model groups. The expression of FN mRNA of the kidney in diabetic rats increased obviously. Shenkang pill could improve the general state and renal function of the diabetic rats, decrease the blood glucose levels and the excretion rate of the 24 hour urine protein and albumin, reduce the expression of FN mRNA in kidney.
CONCLUSIONShenkang pill has a certain protective effect on the diabetic kidney.
