Study on relative bioavailability of ferulic acid of combination Radix Angelicae Sinensis and Cortex Cinnamomi in mice.
- Author:
Zu-yi YANG
1
;
Jin PEI
;
Rong-min LIU
;
Jia CHENG
;
De-guang WAN
;
Rong HU
Author Information
- Publication Type:Journal Article
- MeSH: Angelica sinensis; chemistry; Animals; Biological Availability; Cinnamomum aromaticum; chemistry; Coumaric Acids; blood; pharmacokinetics; Drug Combinations; Drugs, Chinese Herbal; isolation & purification; pharmacokinetics; Female; Male; Mice; Plant Bark; chemistry; Plant Roots; chemistry; Plants, Medicinal; chemistry
- From: China Journal of Chinese Materia Medica 2006;31(12):1012-1015
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the phamacokinetics and relative bioavailability of combination Radix Angelicae Sinensis and Cortex Cinnamomi.
METHODThe content of ferulic acid in plasma was determined directly by HPLC after oral administration of Cortex Cinnamomi in combination individually with Radix Angelicae Sinensis. The plasma concentration-time curve were plotted. The main pharmacokinetic parameters and relative bioavailability were obtained.
RESULTThe plasma concentration-time curve of fenalic aclid conformed to one-compartment model. The relative bioavailability of Cortex Cinnamomi combined with Radix Angelicae Sinensis were 226.75%.
CONCLUSIONBy the statistical analysis, Cortex Cinnamomi combined with Radix Angelicae Sinensis can increase the relative bioavailability of ferulic acid.
