Effect of andrographolide on QS regulating virulence factors production in Pseudomonas aeruginosa.
- Author:
Hong-tao LI
1
;
Hui-min QIN
;
Wei-hua WANG
;
Guo-jun LI
;
Chun-ming WU
;
Jian-xin SONG
Author Information
- Publication Type:Journal Article
- MeSH: Andrographis; chemistry; Anti-Bacterial Agents; pharmacology; Diterpenes; isolation & purification; pharmacology; Pancreatic Elastase; metabolism; Peptide Hydrolases; metabolism; Plants, Medicinal; chemistry; Pseudomonas aeruginosa; growth & development; metabolism; pathogenicity; Pyocyanine; metabolism; Virulence Factors; metabolism
- From: China Journal of Chinese Materia Medica 2006;31(12):1015-1017
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the effect of andrographolide on virulence factors production in Pseudomonas aeruginosa.
METHODGrowth rate, pyocyanin, proteolytic activity and elastase activity were measured with or without the presence of andrographolide. The effect of andrographolide on pyocyanin production, proteolytic activity and elastase activity in PAO-JP2 was investigated simultaneously.
RESULTThe andrographolide did not affect the growth of PAO1 in planktonic culture. The production of pyocyanin, proteolytic activity and elastase activity were significanthy suppressed in P. aeruginosa cultures grown in the presence of andrographolide. However, these effects were not observed in PAO-JP2.
CONCLUSIONThe inhibiting effect of andrographolide on virulence factors production in P. aeruginosa may play a role in its anti-infection activity.
