Effects of fufangdenshen tablets on human atherosclerotic plasma protein using proteomic technique.
- Author:
Zeng-chun MA
1
;
Yue GAO
;
Hong-ling TAN
;
Cheng-rong XIAO
;
Hong-jin WU
;
Sheng-qi WANG
Author Information
- Publication Type:Journal Article
- MeSH: Aged; Coronary Artery Disease; blood; Drug Combinations; Drugs, Chinese Herbal; administration & dosage; isolation & purification; pharmacology; Fibrinogen; metabolism; Granzymes; blood; Humans; Immunoglobulins; blood; Middle Aged; Plants, Medicinal; chemistry; Proteomics; Salvia miltiorrhiza; chemistry; Tablets
- From: China Journal of Chinese Materia Medica 2006;31(9):766-769
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo research the effects of fufangdenshen tablets on atherosclerotic plasma protein using proteomic technique and further explore its potential molecular mechanism to cure atherosclerosis.
METHODThe plasma of normal, atherosclerosis and cured group were collected, and the albumin in plasma was removed. Proteomic protocol involved of 2-DE, image analysis and spectrometry detection was used to detect regulated plasma protein by fufangdenshen tablets.
RESULT3 decreased expressed and 6 higher protein in atherosclerotic plasma could be recovered by fufangdenshen tablets. The levels of fibrinogen, Granzyme C and immunoglobulin were decreased by fufangdenshen tablets.
CONCLUSIONThe levels of fibrinogen, Granzyme C in atherosclerotic plasma could be decreased by fufangdenshen tablets. The effects of fufangdenshen tablets on atherosclerosis included that: inhibition of adhesion of monocyte, inhibition of proliferation and migration of VSMC, and weakening of inflammation.
