Chemical constituents from Viscum nudum and their accelerating PC12 cell differentiation.
- Author:
Hai-Yan ZHU
1
;
Zheng-Wen YU
;
Xiao-Sheng YANG
;
Xiao-Jiang HAO
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Cell Differentiation; drug effects; Chromones; chemistry; isolation & purification; pharmacology; Flavanones; chemistry; isolation & purification; pharmacology; Flavones; chemistry; isolation & purification; pharmacology; Oleanolic Acid; chemistry; isolation & purification; pharmacology; PC12 Cells; cytology; Plant Stems; chemistry; Plants, Medicinal; chemistry; Rats; Viscum; chemistry
- From: China Journal of Chinese Materia Medica 2006;31(16):1340-1342
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate chemical constituents of the stem of Viscum nudum and their bioacyivity.
METHODThe major chemical constituents were isolated from the AcOEt-solved part of ethanol-extract of the plant by column chromatography and the active screening test in vitro were taken out for looking for compounds to acccelerate PC12 cell differentiation.
RESULT5 compounds were identified as eriodictyol (1), 5, 7-dihydroxy-3', 4'-dimethoxy flavanone (2), oleanolic (3), 5, 7-dihydroxychromone (4) and homeriodictyol (5) by spectral evidences, in which homeriodictyol (5) had acceleration differentiation to PC12 cell.
CONCLUSIONAll compounds were obtained from this plant for the first time, and bioactive constituent was observed in the AcOEt-solved part.
