Study on comparative pharmacology of series of Muskone.
- Author:
Kun MA
1
;
Jin-Yan ZHANG
;
Yi-Kui LI
;
Yong-Tao ZHANG
;
Li-Mao WU
;
Xiang-Ri LI
;
Li PAN
;
Lian-Da LI
Author Information
- Publication Type:Journal Article
- MeSH: 6-Ketoprostaglandin F1 alpha; blood; Animals; Aristolochia; chemistry; Cycloparaffins; isolation & purification; pharmacology; Drug Combinations; Drugs, Chinese Herbal; isolation & purification; pharmacology; Endothelins; blood; Female; Inula; chemistry; Male; Mice; Mice, Inbred ICR; Myocardial Infarction; drug therapy; Pain; physiopathology; Plants, Medicinal; chemistry; Rats; Rats, Wistar; Thromboxane B2; blood
- From: China Journal of Chinese Materia Medica 2006;31(16):1353-1357
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the therapeutic effects of the series of Muskone (the Muskone includes Slender Dutchmanspipe Root, Tumuxiang, and not Slender Dutchmanspipe Root) on experimental myocardial infarct and pain in rats.
METHODCoronary artery ligation was applied for the model of myocardial infarct. Therapeutic effects were evaluated by measuring parameters of histomorphometry, blood plasm of ET, 6- keto-PGF1alpha and TXB2. Intraperitoneal injection acetic was applied for the model of ache, the frequency and eclipse period of writhing were evaluated its effect of resisting pain.
RESULTThe Muskone including Radix Aristolociae, the Muskone including Radix Inulae and the Muskone without Radix Aucklandiae all can decrease the area of myocardial infarction in rats, the level of TXB2, ET, and the frequency of writhing significantly. Also it can increase the level 6-keto-PGF1alpha, the ratio of 6-keto-PGF1alpha and TXB2. Single Radix Aristolociae or Radix Inulae only relieved pain.
CONCLUSIONThe Muskone including Radix Aristolociae, the Muskone including Radix Inulae and the Muskone without Radix Aucklandiae all have significant therapeutic effect on both myocardial infarction and pain, while single Radix Aristolociae or Radix Inulae only can relieve pain.
