Improving industrial microbial stress resistance by metabolic engineering: a review.
- Author:
Ruiyan FU
1
;
Yin LI
Author Information
1. School of Tea and Food Science, Anhui Agricultural University, Hefei 230061, China.
- Publication Type:Journal Article
- MeSH:
Bacteria;
genetics;
metabolism;
Bacterial Physiological Phenomena;
Biotechnology;
methods;
Fungi;
genetics;
metabolism;
physiology;
Industrial Microbiology;
methods;
Metabolic Engineering;
methods;
Metabolic Networks and Pathways;
Stress, Physiological
- From:
Chinese Journal of Biotechnology
2010;26(9):1209-1217
- CountryChina
- Language:Chinese
-
Abstract:
Metabolic engineering is a technologic platform for industrial strain improvement and aims not only at modifying microbial metabolic fluxes, but also improving the physiological performance of industrial microbes. Microbes will meet multiple stresses in industrial processes. Consequently, elicited gene responses might result in a decrease in overall cell fitness and the efficiency of biotransformation. Thus, it is crucial to develop robust and productive microbial strains that can be integrated into industrial-scale bioprocesses. In this review, we focus on the progress of these novel methods and strategies for engineering stress-tolerance phenotypes referring to rational metabolic engineering and inverse metabolic engineering in recent years. In addition, we also address problems existing in this area and future research needs of microbial physiological functionality engineering.
