Pluripotency candidate signaling network and transcription factors in domesticated ungulates: a review.
- Author:
Yuncheng ZHAO
1
;
Bo CHEN
;
Chuan ZHOU
;
Xiuhua ZHANG
;
Juncheng HUANG
Author Information
1. Key Laboratory of Animal Biotechnology of Xinjiang, Urumqi 830000, China.
- Publication Type:Journal Article
- MeSH:
Animals;
Animals, Domestic;
Cell Differentiation;
physiology;
Cells, Cultured;
Embryonic Stem Cells;
cytology;
metabolism;
Humans;
Leukemia Inhibitory Factor;
metabolism;
Mice;
Mitogen-Activated Protein Kinase Kinases;
metabolism;
Pluripotent Stem Cells;
cytology;
metabolism;
Sheep;
Signal Transduction;
Transcription Factors;
metabolism;
Wnt Proteins;
metabolism
- From:
Chinese Journal of Biotechnology
2010;26(12):1618-1628
- CountryChina
- Language:Chinese
-
Abstract:
Domesticated ungulates embryonic stem (ES) cells have great significances in biology and wide application prospects. This review compared the key signaling pathways related with pluripotency between mouse and human ES cells, and the difference of transcription factors in mouse, human and domesticated ungulates ES cells were elaborated. Finally the pluripotency candidate signaling network and transcription factors related in the derivation of domesticated ungulates ES cell were discussed combined with practical experience of ovine embryonic stem cell derivation in our laboratory.
