Research advances in association between vitamin D and Kawasaki disease and related mechanisms of action.
- Author:
Xue YANG
1
;
Xiang-Yu DONG
Author Information
1. Department of Pediatrics, Lanzhou University Second Hospital, Lanzhou 730030, China. dxy0223@163.com.
- Publication Type:Journal Article
- MeSH:
Adipokines;
physiology;
Animals;
Blood Platelets;
physiology;
DNA Methylation;
Epithelial Cells;
physiology;
Humans;
Mucocutaneous Lymph Node Syndrome;
etiology;
Vitamin D Deficiency;
complications
- From:
Chinese Journal of Contemporary Pediatrics
2016;18(12):1319-1323
- CountryChina
- Language:Chinese
-
Abstract:
Vitamin D is an important steroid hormone, which has a wide biological effect and is the protective factor against cardiovascular disease and other diseases. At present, the etiology and pathogenesis of Kawasaki disease (KD) remain unknown, but recent studies have shown that vitamin D insufficiency or deficiency is associated with KD. Vitamin D insufficiency or deficiency may affect KD via its influence on inflammatory response, adipokine, endothelial function, platelet function, and DNA methylation and increase the risk of coronary artery lesions. This article reviews the research advances in the association between vitamin D and KD and possible mechanisms of action.
